The study was to assess the effect of agile project management approach and project success. The study population consisted of 30,648 (30,528 beneficiaries (people of Nyamirama sector based on 2012 Rwanda population census,100 community health workers of Nyamirama Sector and 10 staff working in Nyamirama health center and 10 local leaders of Nyamirama sector and 10 SFH Rwanda staff working on the project), Kayonza District, Rwanda. For determining a sample-size, a Slovin’s formula was used-to calculate a sample-size out of the whole study. The formula resulted that the sample-size was 155 respondents. The researcher applied a stratified sampling-technique where sample-size of population in each sampling-frame selected to participate in the survey. A random sampling-technique required where it offers every member of population an equal chance of being included in the sample-size. Primary data collection involves using designed while secondary data was gotten via the existing documents in related field. During the procedure of collecting the data, the questionnaire required to find out the information needed. The statistical-package for social sciences (SPSS) software tool used for data analysis. The findings for overall high mean of 4.10 from heterogeneous of responses, p-value <0.05 and correlation coefficient of 0.813 indicated there is effect of project capacity building on success of Malaria SBCC project at Nyamirama Sector. The findings for overall high mean of 4.12 from heterogeneous of responses, p-value <0.05 and correlation coefficient of 0.805 indicated there is effect of project monitoring on success of Malaria SBCC project at Nyamirama Sector. The findings for overall high mean of 4.24 from heterogeneous of responses, p-value <0.05 and correlation coefficient of 0.667 indicated there is effect of project mediating variables on success of Malaria SBCC project at Nyamirama Sector. Regression analysis results which indicate the effect of project mediating variables, project monitoring and project capacity building on project success. The results as measured by R-square of 0.679 show that 67.9% of total variation on project success of Malaria SBCC Project at Nyamirama Sector can be explained by agile project management. It is essential that SFH Rwanda performs regular monitoring of its projects to verify that the goals of helping recipients improve their socioeconomic well-being are met. Before entering into a partnership, it is essential to do an analysis of the benefits and drawbacks offered by each particular organization. 

Keywords: Agile project management approach, capacity building, monitoring, mediating variables and project success