The study investigated natural disaster preparedness and sustainable development in Rutsiro District, Republic of Rwanda. Specific objectives were to assess natural disaster preparedness strategies used; identify effects of natural disasters on sustainable development; evaluate strength of natural disaster strategies in place aimed at sustainable development; and lasting strategies on disaster preparedness management for sustainable development. A descriptive research design with quantitative and qualitative approaches was applied in the study. Target population was 324,654 from whom 133 mature and educated people were conveniently chosen from Rutsiro. Simple random sampling technique was used to select 100 respondents as the sample size. Data collection methods were questionnaire, interview guide and documents review. Data analysis applied descriptive statistic methods. Findings showed that natural disaster preparedness strategies through creating a community or national emergency operation plan were used as confirmed by more than 85% of respondents. Seventy-four percent (74%) confirmed that the effects of natural disasters on sustainable development of Rutsiro District exist. Eighty percent (80%) affirmed that strength of natural disaster strategies aimed at sustainable development were in place. Lasting strategies on disaster preparedness management for sustainable development were confirmed where measures to activate special installation such as mobile hospital facilities to help to reduce disaster risk were identified. Based on the findings, the study concluded that natural disaster preparedness boosts sustainable development and shields Rutsiro’s citizens from being a high risk zone of disaster. The researcher recommended that natural disaster preparedness requires people to know and follow the methods of construction, use and combination of specific materials and ways of being resilient enough to disaster incidences.